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No. de sistema: 000009641

LDR _ _ 00000nab^^22^^^^^za^4500
008 _ _ 200907m20209999xx^^r^p^o^^^^z0^^^a0eng^d
040 _ _ a| ECO
c| ECO
044 _ _ a| xx
245 0 0 a| Immunomodulatory effect of Lactobacillus casei in a murine model of colon carcinogenesis
506 _ _ a| Disponible para usuarios de ECOSUR con su clave de acceso
520 1 _ a| We previously reported beneficial effects of the probiotic strain Lactobacillus casei 393 in hindering colon carcinogenesis in a 1,2-dimethylhydrazine (DMH)-induced BALB/c mouse model of colon cancer. In the present study, we investigated the effect of preventive administration of L. casei 393 on the levels of selected pro- and anti-inflammatory circulating cytokines, as well as subpopulations of splenic T cells. The resulting experimental data on IFNγ, TNFα, IL-10, and colon histological features demonstrated that administration of L. casei 2 weeks before DMH treatment impaired the pro-inflammatory effect of DMH, while maintaining the levels of the three cytokines as well as colon histology; it also modulated splenic CD4+, CD8+, and NK T cell subpopulations. The preventive administration of L. casei to DMH-treated mice increased IL-17A synthesis and Treg percentages, further indicating a tumor-protecting role. Together, the results suggest that the colon-cancer-protective properties of L. casei 393 involve the dampening of inflammation through cytokine homeostasis and the maintenance of a healthy T cell subpopulation dynamic. For these reasons, probiotics such as L. casei may contribute to the health of the host as they promote optimal control of the immune response. Further, they may be used as prophylactic agents in combination with standard therapies against colon cancer.
530 _ _ a| Disponible en línea
533 _ _ a| Reproducción electrónica en formato PDF
538 _ _ a| Adobe Acrobat profesional 6.0 o superior
650 _ 4 a| Lactobacillus casei
650 _ 4 a| Probióticos
650 _ 4 a| Carcinogénesis de cólon
700 1 _ a| Casas Solís, Josefina
e| autora
700 1 _ a| Huizar López, María del Rosario
e| autora
700 1 _ a| Irecta Nájera, César Antonio
c| Doctor
e| autor
700 1 _ a| Pita López, María Luisa
e| autora
700 1 _ a| Santerre, Anne
e| autora
773 0 _
t| Probiotics and Antimicrobial Proteins
g| Volumen 12, número 3 (September 2020), p. 1012-1024
x| 1867-1314
900 _ _ a| Solicítelo con su bibliotecario/a
901 _ _ a| Artículo con arbitraje
902 _ _ a| BG / MM
904 _ _ a| Septiembre 2020
905 _ _ a| Artecosur
905 _ _ a| Biblioelectrónica
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*Solicítelo con su bibliotecario/a
Immunomodulatory effect of Lactobacillus casei in a murine model of colon carcinogenesis
Casas Solís, Josefina (autora)
Huizar López, María del Rosario (autora)
Irecta Nájera, César Antonio (autor)
Pita López, María Luisa (autora)
Santerre, Anne (autora)
Nota: Disponible en línea
Disponible para usuarios de ECOSUR con su clave de acceso
Contenido en: Probiotics and Antimicrobial Proteins. Volumen 12, número 3 (September 2020), p. 1012-1024. ISSN: 1867-1314
No. de sistema: 9641
Tipo: - Artículo con arbitraje
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"We previously reported beneficial effects of the probiotic strain Lactobacillus casei 393 in hindering colon carcinogenesis in a 1,2-dimethylhydrazine (DMH)-induced BALB/c mouse model of colon cancer. In the present study, we investigated the effect of preventive administration of L. casei 393 on the levels of selected pro- and anti-inflammatory circulating cytokines, as well as subpopulations of splenic T cells. The resulting experimental data on IFNγ, TNFα, IL-10, and colon histological features demonstrated that administration of L. casei 2 weeks before DMH treatment impaired the pro-inflammatory effect of DMH, while maintaining the levels of the three cytokines as well as colon histology; it also modulated splenic CD4+, CD8+, and NK T cell subpopulations. The preventive administration of L. casei to DMH-treated mice increased IL-17A synthesis and Treg percentages, further indicating a tumor-protecting role. Together, the results suggest that the colon-cancer-protective properties of L. casei 393 involve the dampening of inflammation through cytokine homeostasis and the maintenance of a healthy T cell subpopulation dynamic. For these reasons, probiotics such as L. casei may contribute to the health of the host as they promote optimal control of the immune response. Further, they may be used as prophylactic agents in combination with standard therapies against colon cancer."


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