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No. de sistema: 000058106

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008 _ _ 170126m20169999xx^^r^p^^^^^^z0^^^a0eng^d
040 _ _ a| ECO
c| ECO
043 _ _ a| n-mx-sl
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245 0 0 a| Pharmacological effects and toxicity of Costus pulverulentus C. Presl (Costaceae) 
506 _ _ a| Acceso electrónico sólo para usuarios de ECOSUR
520 1 _ a| Ethnopharmacological relevance: Costus pulverulentus C. Presl (Costaceae), a species endemic to Mexico, is used for the empirical treatment of cancer, pain, and inflammation. Aim of the study: The objective of this study was to evaluate the toxicity, as well as the cytotoxic, antinociceptive, anti-inflammatory and sedative effects of an ethanol extract from Costus pulverulentus stem (CPE). Materials and methods: The chemical characterization of CPE was performed by Gas chromatography–mass spectrometry (GC–MS). The toxicity of CPE was evaluated using the comet assay (10–1000 µg/ml during 5 h) and the acute toxicity test (500–5000 mg/kg p.o. and i.p. during 14 days). The cytotoxic effect of CPE (1–250 µg/ml) on human cancer cells was evaluated using the MTT assay. The antinociceptive effects of CPE (50–200 mg/kg p.o.) were evaluated using thermal-induced nociception tests (hot plate and tail flick) and the chemical-induced nociceptive tests (acetic acid and formalin). The sedative activity of CPE (50–200 mg/kg p.o.) was evaluated using the ketamine-induced sleeping time test.
520 1 _ a| Results: CPE showed the presence of compounds such as campesterol, stigmasterol β-sitosterol, vanillicacid, among others. In the comet assay, CPE at 200 µg/ml or higher concentrations induced DNA damage. In the acute toxicity test, the LD 50 estimated for CPE was > 5000 mg/kg p.o. or i.p. CEP showed moderate cytotoxic effects on prostate carcinoma cells PC-3 cells (IC 50=179+23.2 µg/ml). In the chemical-induced nociception models, CPE (100 and 200 mg/kg p.o.) showed antinociceptive effects with similar activity to 100 mg/kg naproxen. In the thermal-induced nociception tests, CPE tested at 200 mg/kg showed moderate antinociceptive effects by 28% (hot plate test) and by 25% (tail fl ick test). In the ketamine-induced sleeping time test, CPE showed no sedative effects. Conclusions: C. pulverulents exerts moderate cytotoxic effects in human cancer cells, moderate anti-inflammatory and antinociceptive effects. C. pulverulentus induces antinociceptive effects without inducing sedation.
650 _ 4 a| Costus pulverulentus
650 _ 4 a| Plantas medicinales
650 _ 4 a| Composición química
650 _ 4 a| Toxicidad
650 _ 4 a| Analgésicos
650 _ 4 a| Cáncer
650 _ 4 a| Antiinflamatorios
650 _ 4 a| Etnofarmacología
651 _ 4 a| Aquismón (San Luis Potosí, México)
700 1 _ a| Alonso Castro, Ángel Josabad
e| autor
700 1 _ a| Zapata Morales, Juan Ramón
e| autor
700 1 _ a| González Chávez, Marco Martin
e| autor
700 1 _ a| Carranza Álvarez, Candy
e| autora
700 1 _ a| Hernández Benavides, Diego Manuel
e| autor
700 1 _ a| Hernández Morales, Alejandro
e| autor
773 0 _
t| Journal of Ethnopharmacology
g| Vol. 180 (March 2016), p. 124–130
x| 0378-8741
900 _ _ a| Solicítelo con su bibliotecario/a
902 _ _ a| BG / MM
904 _ _ a| Enero 2017
905 _ _ a| Artecosur
905 _ _ a| Biblioelectrónica
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Pharmacological effects and toxicity of Costus pulverulentus C. Presl (Costaceae) 
Alonso Castro, Ángel Josabad (autor)
Zapata Morales, Juan Ramón (autor)
González Chávez, Marco Martin (autor)
Carranza Álvarez, Candy (autora)
Hernández Benavides, Diego Manuel (autor)
Hernández Morales, Alejandro (autor)
Nota: Acceso electrónico sólo para usuarios de ECOSUR
Contenido en: Journal of Ethnopharmacology. Vol. 180 (March 2016), p. 124–130. ISSN: 0378-8741
No. de sistema: 58106
Tipo: Artículo
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Inglés

"Ethnopharmacological relevance: Costus pulverulentus C. Presl (Costaceae), a species endemic to Mexico, is used for the empirical treatment of cancer, pain, and inflammation. Aim of the study: The objective of this study was to evaluate the toxicity, as well as the cytotoxic, antinociceptive, anti-inflammatory and sedative effects of an ethanol extract from Costus pulverulentus stem (CPE). Materials and methods: The chemical characterization of CPE was performed by Gas chromatography–mass spectrometry (GC–MS). The toxicity of CPE was evaluated using the comet assay (10–1000 µg/ml during 5 h) and the acute toxicity test (500–5000 mg/kg p.o. and i.p. during 14 days). The cytotoxic effect of CPE (1–250 µg/ml) on human cancer cells was evaluated using the MTT assay. The antinociceptive effects of CPE (50–200 mg/kg p.o.) were evaluated using thermal-induced nociception tests (hot plate and tail flick) and the chemical-induced nociceptive tests (acetic acid and formalin). The sedative activity of CPE (50–200 mg/kg p.o.) was evaluated using the ketamine-induced sleeping time test."

"Results: CPE showed the presence of compounds such as campesterol, stigmasterol β-sitosterol, vanillicacid, among others. In the comet assay, CPE at 200 µg/ml or higher concentrations induced DNA damage. In the acute toxicity test, the LD 50 estimated for CPE was > 5000 mg/kg p.o. or i.p. CEP showed moderate cytotoxic effects on prostate carcinoma cells PC-3 cells (IC 50=179+23.2 µg/ml). In the chemical-induced nociception models, CPE (100 and 200 mg/kg p.o.) showed antinociceptive effects with similar activity to 100 mg/kg naproxen. In the thermal-induced nociception tests, CPE tested at 200 mg/kg showed moderate antinociceptive effects by 28% (hot plate test) and by 25% (tail fl ick test). In the ketamine-induced sleeping time test, CPE showed no sedative effects. Conclusions: C. pulverulents exerts moderate cytotoxic effects in human cancer cells, moderate anti-inflammatory and antinociceptive effects. C. pulverulentus induces antinociceptive effects without inducing sedation."