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In vitro nematocidal activity of commercial fatty acids and β-sitosterol against Haemonchus contortus

Pineda Alegría, Jesús Antonio [autor] | Sánchez, José E [autor] | González Cortázar, Manasés [autor] | Von Son de Fernex, Elke [autora] | González Garduño, Roberto [autor] | Mendoza de Gives, Pedro [autor] | Zamilpa, Alejandro [autor] | Aguilar Marcelino, Liliana [autora].
Tipo de material: Artículo en línea Artículo en línea Tema(s): Haemonchus contortus | Nemátodos parásitos de animales | Rumiantes | Control de nemátodosTema(s) en inglés: Haemonchus contortus | Animal parasitic nematodes | Ruminants | Nematode controlNota de acceso: Disponible para usuarios de ECOSUR con su clave de acceso En: Journal of Helminthology. volumen 94, e135 (2020), páginas 1-4. --ISSN: 1475-2697Número de sistema: 60027Resumen:
Inglés

Haemonchus contortusis a haematophagous gastrointestinal nematode (GIN) that causes severe anaemia and even death in small ruminants, negatively impacting the economic viability of farms. Traditionally, this parasite has been controlled with chemical compounds; however, inadequate use of these types of products has favoured the emergence of anthelmintic resistance. Therefore, it is necessary to search for alternatives for GIN control. Previous studies have reported the anthelmintic activity of edible mushroom extracts against H. contortus. A recent study reported that a fraction constituted of different fatty acids and β-sitosterol isolated from the basidiomata of the edible mushroom Pleurotus djamor ECS-123 has ovicidal and larvicidal activity against H. contortus. Thus, this study aimed to assess the anthelmintic activity of the pure molecules: pentadecanoic acid, palmitic acid, β-sitosterol, stearic acid and linoleic acid. For this purpose, an egg-hatching inhibition test was carried out in which the compounds were evaluated individually and in combination at a final concentration of 20 mg mL−¹. Furthermore, larval mortality was assessed using a combination of the five commercial compounds previously mentioned at different concentrations (1.25-20 mg mL−¹). Palmitic acid and stearic acid, in some combinations, inhibited H. contortus egg hatching by 100%. On the other hand, in the larval mortality test, the combination of the five compounds showed dose-dependent behaviour, and 100% mortality was obtained 24 h post-incubation. Pure molecules and their combinations have anthelmintic-like activity against the eggs and larvae of H. contortus.

Recurso en línea: https://www.cambridge.org/core/journals/journal-of-helminthology/article/in-vitro-nematocidal-activity-of-commercial-fatty-acids-and-sitosterol-against-haemonchus-contortus/B53CB9631E493315D1F8297B483D9BFF
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Haemonchus contortusis a haematophagous gastrointestinal nematode (GIN) that causes severe anaemia and even death in small ruminants, negatively impacting the economic viability of farms. Traditionally, this parasite has been controlled with chemical compounds; however, inadequate use of these types of products has favoured the emergence of anthelmintic resistance. Therefore, it is necessary to search for alternatives for GIN control. Previous studies have reported the anthelmintic activity of edible mushroom extracts against H. contortus. A recent study reported that a fraction constituted of different fatty acids and β-sitosterol isolated from the basidiomata of the edible mushroom Pleurotus djamor ECS-123 has ovicidal and larvicidal activity against H. contortus. Thus, this study aimed to assess the anthelmintic activity of the pure molecules: pentadecanoic acid, palmitic acid, β-sitosterol, stearic acid and linoleic acid. For this purpose, an egg-hatching inhibition test was carried out in which the compounds were evaluated individually and in combination at a final concentration of 20 mg mL−¹. Furthermore, larval mortality was assessed using a combination of the five commercial compounds previously mentioned at different concentrations (1.25-20 mg mL−¹). Palmitic acid and stearic acid, in some combinations, inhibited H. contortus egg hatching by 100%. On the other hand, in the larval mortality test, the combination of the five compounds showed dose-dependent behaviour, and 100% mortality was obtained 24 h post-incubation. Pure molecules and their combinations have anthelmintic-like activity against the eggs and larvae of H. contortus. eng

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