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No. de sistema: 000060027

LDR _ _ 00000nab^^22^^^^^za^4500
008 _ _ 200317m20209999xx^^r^p^o^^^^z0^^^a0eng^d
040 _ _ a| ECO
c| ECO
044 _ _ a| xx
245 0 0 a| In vitro nematocidal activity of commercial fatty acids and β-sitosterol against Haemonchus contortus
506 _ _ a| Disponible para usuarios de ECOSUR con su clave de acceso
520 1 _ a| Haemonchus contortusis a haematophagous gastrointestinal nematode (GIN) that causes severe anaemia and even death in small ruminants, negatively impacting the economic viability of farms. Traditionally, this parasite has been controlled with chemical compounds; however, inadequate use of these types of products has favoured the emergence of anthelmintic resistance. Therefore, it is necessary to search for alternatives for GIN control. Previous studies have reported the anthelmintic activity of edible mushroom extracts against H. contortus. A recent study reported that a fraction constituted of different fatty acids and β-sitosterol isolated from the basidiomata of the edible mushroom Pleurotus djamor ECS-123 has ovicidal and larvicidal activity against H. contortus. Thus, this study aimed to assess the anthelmintic activity of the pure molecules: pentadecanoic acid, palmitic acid, β-sitosterol, stearic acid and linoleic acid. For this purpose, an egg-hatching inhibition test was carried out in which the compounds were evaluated individually and in combination at a final concentration of 20 mg mL−¹. Furthermore, larval mortality was assessed using a combination of the five commercial compounds previously mentioned at different concentrations (1.25–20 mg mL−¹). Palmitic acid and stearic acid, in some combinations, inhibited H. contortus egg hatching by 100%. On the other hand, in the larval mortality test, the combination of the five compounds showed dose-dependent behaviour, and 100% mortality was obtained 24 h post-incubation. Pure molecules and their combinations have anthelmintic-like activity against the eggs and larvae of H. contortus.
533 _ _ a| Reproducción electrónica en formato PDF
538 _ _ a| Adobe Acrobat profesional 6.0 o superior
650 _ 4 a| Haemonchus contortus
650 _ 4 a| Nemátodos parásitos de animales
650 _ 4 a| Rumiantes
650 _ 4 a| Control de nemátodos
700 1 _ a| Pineda Alegría, Jesús Antonio
e| autor
700 1 _ a| Sánchez, José E.
e| autor
n| 55452597200
700 1 _ a| González Cortázar, Manáses
e| autor
700 1 _ a| Von Son de Fernex, Elke
e| autora
700 1 _ a| González Garduño, Roberto
e| autor
700 1 _ a| Mendoza de Gives, Pedro
e| autor
700 1 _ a| Zamilpa, Alejandro
e| autor
700 1 _ a| Aguilar Marcelino, Liliana
e| autora
773 0 _
t| Journal of Helminthology
g| Vol. 94, e135 (2020), p. 1-4
x| 1475-2697
900 _ _ a| Solicítelo con su bibliotecario/a
902 _ _ a| BG / MM
904 _ _ a| Marzo 2020
905 _ _ a| Artecosur
905 _ _ a| Biblioelectrónica
LNG eng
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In vitro nematocidal activity of commercial fatty acids and β-sitosterol against Haemonchus contortus
Pineda Alegría, Jesús Antonio (autor)
Sánchez, José E. (autor)
González Cortázar, Manáses (autor)
Von Son de Fernex, Elke (autora)
González Garduño, Roberto (autor)
Mendoza de Gives, Pedro (autor)
Zamilpa, Alejandro (autor)
Aguilar Marcelino, Liliana (autora)
Nota: Disponible para usuarios de ECOSUR con su clave de acceso
Contenido en: Journal of Helminthology. Vol. 94, e135 (2020), p. 1-4. ISSN: 1475-2697
No. de sistema: 60027
Tipo: Artículo
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Inglés

"Haemonchus contortusis a haematophagous gastrointestinal nematode (GIN) that causes severe anaemia and even death in small ruminants, negatively impacting the economic viability of farms. Traditionally, this parasite has been controlled with chemical compounds; however, inadequate use of these types of products has favoured the emergence of anthelmintic resistance. Therefore, it is necessary to search for alternatives for GIN control. Previous studies have reported the anthelmintic activity of edible mushroom extracts against H. contortus. A recent study reported that a fraction constituted of different fatty acids and β-sitosterol isolated from the basidiomata of the edible mushroom Pleurotus djamor ECS-123 has ovicidal and larvicidal activity against H. contortus. Thus, this study aimed to assess the anthelmintic activity of the pure molecules: pentadecanoic acid, palmitic acid, β-sitosterol, stearic acid and linoleic acid. For this purpose, an egg-hatching inhibition test was carried out in which the compounds were evaluated individually and in combination at a final concentration of 20 mg mL−¹. Furthermore, larval mortality was assessed using a combination of the five commercial compounds previously mentioned at different concentrations (1.25–20 mg mL−¹). Palmitic acid and stearic acid, in some combinations, inhibited H. contortus egg hatching by 100%. On the other hand, in the larval mortality test, the combination of the five compounds showed dose-dependent behaviour, and 100% mortality was obtained 24 h post-incubation. Pure molecules and their combinations have anthelmintic-like activity against the eggs and larvae of H. contortus."


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