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6 resultados encontrados para: AUTOR: Fajardo, Victor
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1.
- Artículo con arbitraje
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Hypoxia by altitude and welfare of captive beaded lizards (Heloderma Horridum) in Mexico: hematological approaches
Guadarrama, Sonia S. :: autora ; Domínguez Vega, Hublester (autor) ; Díaz Albíter, Héctor Manuel (autor) ; Quijano, Alejandro (autor) ; Bastiaans, Elizabeth (autora) ; Carrillo-Castilla, Porfirio (autor) ; Manjarrez, Javier (autor) ; Gómez Ortíz, Yuriana (autora) ; Fajardo, Victor (autor) ;
Contenido en: Journal of Applied Animal Welfare Science Vol. 23, no. 1 (2020), p. 74–82 ISSN: 1532-7604
Nota: Solicítelo con su bibliotecario/a
Resumen en: Inglés |
Resumen en inglés

Heloderma horridum is one of the few known venomous lizards in the world. Their populations are in decline due to habitat destruction and capture for the pet trade. InMéxico, many zoos have decided to take care of this species, most of them at altitudes greater than the natural altitudinal distribution. However, we know little about the capacity of the reptiles to face high-altitude environments. The objective of this study was to compare hematological traits of H. horridumin captivity in high and low altitude environments. Our findings show that H. horridum does not respond to hypoxic environments, at least in blood traits, and that the organisms appear to be in homeostasis. Although we cannot know if individual H. horridum housed in high-altitude environments are completely comfortable, it appears hypoxia can be avoid without modifications of blood parameters. We suggest that future work should address changes in metabolic rates and in behavioral aspects to understand how to maintain the health and comfort of the reptiles native to low altitude when they are housed in high-altitude environments.


2.
- Artículo con arbitraje
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Resumen en: Inglés |
Resumen en inglés

In this paper, we have identified and analyzed the emergence, structure and dynamics of the paradigmatic research fronts that established the fundamentals of the biomedical knowledge on HIV/AIDS. A search of papers with the identifiers "HIV/AIDS", "Human Immunodeficiency Virus", ªHIV-1º and "Acquired Immunodeficiency Syndrome" in the Web of Science (Thomson Reuters), was carried out. A citation network of those papers was constructed. Then, a sub-network of the papers with the highest number of inter-citations (with a minimal in-degree of 28) was selected to perform a combination of network clustering and text mining to identify the paradigmatic research fronts and analyze their dynamics. Thirteen research fronts were identified in this sub-network. The biggest and oldest front is related to the clinical knowledge on the disease in the patient. Nine of the fronts are related to the study of specific molecular structures and mechanisms and two of these fronts are related to the development of drugs. The rest of the fronts are related to the study of the disease at the cellular level. Interestingly, the emergence of these fronts occurred in successive "waves" over the time which suggest a transition in the paradigmatic focus. The emergence and evolution of the biomedical fronts in HIV/AIDS research is explained not just by the partition of the problem in elements and interactions leading to increasingly specialized communities, but also by changes in the technological context of this health problem and the dramatic changes in the epidemiological reality of HIV/AIDS that occurred between 1993 and 1995.


3.
- Artículo con arbitraje
Liposomes versus metallic nanostructures: differences in the process of knowledge translation in cancer
Fajardo Ortiz, David Guillermo (autor) ; Duran, Luis (autor) ; Moreno, Laura (autora) ; Ochoa Díaz López, Héctor (autor) ; Castaño Meneses, Víctor Manuel (coaut.) ;
Contenido en: International Journal of Nanomedicine Vol. 9, no. 1 (May 2014), p. 2627-2634 ISSN: 1178-2013
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Resumen en: Inglés |
Resumen en inglés

This research maps the knowledge translation process for two different types of nanotechnologies applied to cancer: liposomes and metallic nanostructures (MNs). We performed a structural analysis of citation networks and text mining supported in controlled vocabularies. In the case of liposomes, our results identify subnetworks (invisible colleges) associated with different therapeutic strategies: nanopharmacology, hyperthermia, and gene therapy. Only in the pharmacological strategy was an organized knowledge translation process identified, which, however, is monopolized by the liposomal doxorubicins. In the case of MNs, subnetworks are not differentiated by the type of therapeutic strategy, and the content of the documents is still basic research. Research on MNs is highly focused on developing a combination of molecular imaging and photothermal therapy.


4.
- Artículo con arbitraje
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Resumen en: Inglés |
Resumen en inglés

We explored how the knowledge translation and innovation processes are structured when theyresult in innovations, as in the case of liposomal doxorubicin research. In order to map the processes, a literature network analysis was made through Cytoscape and semantic analysis was performed by GOPubmed which is based in the controlled vocabularies MeSH (Medical Subject Headings) and GO (Gene Ontology). We found clusters related to different stages of the technological development (invention, innovation and imitation) and the knowledge translation process (preclinical, translational and clinical research), and we were able to map the historic emergence of Doxil as a paradigmatic nanodrug. This research could be a powerful methodological tool for decision-making and innovation management in drug delivery research.


5.
- Artículo con arbitraje
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Resumen en: Español | Inglés | Portugués |
Resumen en español

En este trabajo construimos un mapa de la traducción del conocimiento sobre cáncer cervicouterino, basado en el análisis de redes de citación y en el uso de términos del “Gene Ontology” y del Medical Heading Subject. Identificamos dos campos de investigación sobre cáncer cervicouterino, pobremente conectados entre sí, que difieren en estructura, contenido y evolución. Un área esta centrada en el estudio de las causas de la enfermedad, mientras que la otra se centra en la atención al paciente. En la primera área encontramos un proceso de traducción del conocimiento en la que la investigación clínica y la investigación básica se comunican a través de un conjunto de artículos que consolidan la infección por el papilomavirus como la causa necesaria del cáncer cervicouterino. La primera área está orientada a prevenir la infección por el virus del papiloma humano y el subsecuente desarrollo del cáncer cervicouterino, mientras que la otra área se ocupa de la estadificación y tratamiento de la enfermedad.

Resumen en inglés

This article constructs a map on the translation of knowledge concerning cervical cancer, based on citation networks analysis and the use of Gene Ontology terms and Medical Subject Headings. We identified two areas of research that are poorly interconnected and differ in structure, content, and evolution. One focuses on causes of cancer and the other on patient care. The first research area showed a knowledge translation process where basic research and clinical research are communicated through a set of articles that consolidate human papillomavirus infection as the necessary cause of cervical cancer. The first area aims to prevent HPV infection and the development of cervical cancer, while the second aims to stage and treat the disease.

Resumen en portugués

Neste trabalho, construímos um mapa da tradução do conhecimento em câncer do colo do útero com base na análise de redes, a citação e o uso de termos do Gene Ontology e do Medical Subject Headings. Foram identificadas duas áreas de pesquisa que estão mal interligadas e diferem na estrutura, conteúdo e evolução. Uma área é centrada no estudo das causas da doença, enquanto a outra é focada no tratamento do paciente. Na primeira área de pesquisa encontramos um processo de tradução do conhecimento em que a pesquisa básica e a pesquisa clínica são comunicadas por um conjunto de documentos que consolidam a infecção pelo papilomavírus humano como a causa necessária de câncer cervical. A primeira área é destinada a prevenir a infecção por HPV e no desenvolvimento de cancro, enquanto a segunda é destinado a estadiamento e tratamento da doença.


6.
Tesis - Maestría
Análisis de un proceso de traducción del conocimiento en salud: el caso del cáncer cervicouterino / David Guillermo Fajardo Ortiz
Fajardo Ortiz, David Guillermo ; Ochoa Díaz López, Héctor (tutor) ; Castaño Meneses, Víctor Manuel (asesor) ; García Barrios, Luis Enrique (asesor) ;
San Cristóbal de Las Casas, Chiapas, México : El Colegio de la Frontera Sur , 2012
Clasificación: TE/616.99466 / F3
Cerrar
SIBE Campeche
ECO040004954 (Disponible)
Disponibles para prestamo: 1
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SIBE Chetumal
ECO030007702 (Disponible)
Disponibles para prestamo: 1
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SIBE San Cristóbal
ECO010008379 (Disponible)
Disponibles para prestamo: 1
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SIBE Tapachula
ECO020012800 (Disponible)
Disponibles para prestamo: 1
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SIBE Villahermosa
ECO050002665 (Disponible)
Disponibles para prestamo: 1
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Resumen en: Español | Inglés |
Resumen en español

En este trabajo construimos un mapa de la traducción del conocimiento sobre cáncer cervicouterino basado en el análisis de redes de citación del 10% de los artículos de investigación más citados. Identificamos dos campos de investigación sobre cáncer cervicouterino pobremente conectados entre sí que difieren en estructura, contenido y evolución. Una área está centrada en el estudio de las causas de la enfermedad mientras que la otra área se centra en la atención al paciente. En la primera área encontramos un proceso de traducción del conocimiento en la que la investigación clínica y la investigación básica se comunican a través de un conjunto de artículos que consolidan a la infección por el papilomavirus como la causa necesaria del cáncer cervicouterino. Mientras que en estudio de la atención al paciente, no hay una traducción del conocimiento. En este estudio no se encontraron representados otros campos de investigación que pudieran integrar y orientar a los dos anteriores como son el estudio de las determinantes sociales de la enfermedad o la investigación sobre sistemas de salud.

Resumen en inglés

The translation of knowledge in cervical cancer; Is there a gap between research on the causes and research on patient care? In this paper we constructed a map of the knowledge translation in cervical cancer based on the citation network analysis 10% of the most cited research papers. We identified two areas of research which are poorly interconnected and differ in structure, content and evolution. One area is focused on the study of the causes of the disease while the other it is focused on patient care. In the first research area we found a knowledge translation process in which basic research and clinical research are communicated through a set of papers that consolidate the human papilloma virus infection as the necessary cause of cervical cancer. Where as in the patient care research area, there is no knowledge translation. In this study, there was no representation from other research fields that could integrate and guide the two previous such as the study of the social determinants of disease or health systems research.