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2 resultados encontrados para: AUTOR: Huizar López, María del Rosario
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1.
- Artículo con arbitraje
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Immunomodulatory effect of Lactobacillus casei in a murine model of colon carcinogenesis
Casas Solís, Josefina (autora) ; Huizar López, María del Rosario (autora) ; Irecta Nájera, César Antonio (autor) ; Pita López, María Luisa (autora) ; Santerre, Anne (autora) ;
Disponible en línea
Contenido en: Probiotics and Antimicrobial Proteins Volumen 12, número 3 (September 2020), p. 1012-1024 ISSN: 1867-1314
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Resumen en: Inglés |
Resumen en inglés

We previously reported beneficial effects of the probiotic strain Lactobacillus casei 393 in hindering colon carcinogenesis in a 1,2-dimethylhydrazine (DMH)-induced BALB/c mouse model of colon cancer. In the present study, we investigated the effect of preventive administration of L. casei 393 on the levels of selected pro- and anti-inflammatory circulating cytokines, as well as subpopulations of splenic T cells. The resulting experimental data on IFNγ, TNFα, IL-10, and colon histological features demonstrated that administration of L. casei 2 weeks before DMH treatment impaired the pro-inflammatory effect of DMH, while maintaining the levels of the three cytokines as well as colon histology; it also modulated splenic CD4+, CD8+, and NK T cell subpopulations. The preventive administration of L. casei to DMH-treated mice increased IL-17A synthesis and Treg percentages, further indicating a tumor-protecting role. Together, the results suggest that the colon-cancer-protective properties of L. casei 393 involve the dampening of inflammation through cytokine homeostasis and the maintenance of a healthy T cell subpopulation dynamic. For these reasons, probiotics such as L. casei may contribute to the health of the host as they promote optimal control of the immune response. Further, they may be used as prophylactic agents in combination with standard therapies against colon cancer.


2.
- Artículo con arbitraje
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Protective effect of Lactobacillus casei on DMH-induced colon carcinogenesis in mice
Irecta Nájera, César Antonio (autor) ; Huizar López, María del Rosario (autora) ; Casas Solís, Josefina (autora) ; Castro Félix, Patricia (autora) ; Santerre, Anne (autora) ;
Disponible en línea
Contenido en: Probiotics and Antimicrobial Proteins Vol. 9, no. 2 (June 2017), p. 163–171 ISSN: 1867-1314
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Resumen en: Inglés |
Resumen en inglés

The administration of probiotics is a promising approach to reduce the prevalence of colon cancer, a multifactorial disease, with hereditary factors, as well as environmental lifestyle-related risk factors. Biogenic polyamines, putrescine, spermidine, and spermine are small cationic molecules with great roles in cell proliferation and differentiation as well as regulation of gene expression. Ornithine decarboxylase is the first rate-limiting enzyme for polyamine synthesis, and upregulation of ornithine decarboxylase activity and polyamine metabolism has been associated with abnormal cell proliferation. This paper is focused on studying the protective role of Lactobacillus casei ATCC 393 in a chemically induced mouse model of colon carcinogenesis, directing our attention on aberrant crypt foci as preneoplastic markers, and on polyamine metabolism as a possible key player in carcinogenesis. BALB/c mice were administered 1,2-dimethylhydrazine dihydrochloride (DMH) to induce colon cancer (20 mg/kg body weight, subcutaneous, twice a week for 24 weeks). L. casei ATCC 393 was given orally (10 6 CFU, twice a week), 2 weeks before DMH administration. Hematoxylin and eosin staining, high-performance liquid chromatography, and Western blotting were used to evaluate aberrant crypt foci, urinary polyamines, and ornithine decarboxylase expression in the colon. The experimental data showed that the preventive administration of L. casei ATCC 393 may delay the onset of cancer as it significantly reduced the number of DMH-induced aberrant crypt foci, the levels of putrescine, and the expression of ornithine decarboxylase. Hence, this probiotic strain has a prospective role in protection against colon carcinogenesis, and its antimutagenic activity may be associated with the maintenance of polyamine metabolism.